Publications
- Yount, R.G., Simchuk, S., Yu, I., and Kottke, M. (1966). Adenosine-5'-sulfatopyrophosphate, an analogue of adenosine triphosphate. I. Preparation, properties, and mode of cleavage by snake venoms. Arch. Biochem. Biophys. 113:288-295.
- Yount, R.G., Yu, I., and Simchuk, S. (1966). Adenosine-5'-sulfatopyrophosphate, an analogue of adenosine triphosphate. II. Interaction with myosin, actomyosin, and muscle fibers. Arch. Biochem. Biophys. 113:296-303.
- Leonard, S., Arbogast, D., Geyer, D., Jones, C., and Sinensky, M. (1986). Localization of the gene encoding 3-hydroxy-3-methylglutaryl CoA synthase to human chromosome 5. Proc. Natl. Acad. Sci. 83:2187-2189.
- Leonard, S. and Sinensky, M. (1988). Somatic cell genetics and the study of cholesterol metabolism. (Review). Biochim. Biophys. Act. 947:101-112.
- Peffly, D., Miyake, J., Leonard, S., von Gunten, C., and Sinensky, M. (1988). Further characterization of a somatic cell mutant defective in regulation of 3-hydroxy-3-methylglutaryl coemzyme A reductase. Som. Cell Mol. Gen. 14:527-539.
- Leonard, S., Beck, L., and Sinensky, M. (1990). Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21ras. J. Biol. Chem. 265:5157-5160.
- Panini, S.R., Lutz, R.J., Wenger, L., Miyake, J., Leonard, S., Andalibi, A., Lusis, A.J., and Sinensky, M. (1990). Defective elongation of fatty acids in a recessive 25-hydroxycholesterol resistant mutant cell line. J. Biol. Chem. 265:14118-14126.
- Sinensky, M., Beck, L.A., Leonard, S., and Evans, R. (1990). Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J. Biol. Chem. 265:19937-19941.
- Logel, J., Dill, D., and Leonard, S. (1992). Synthesis of cRNA probes from PCR-generated DNA. BioTechniques 13 (4):604-610.
- Hall, M., Zerbe, L., Leonard, S., and Freedman, R. (1993). Characterization of [3H] cytisine binding to human brain membrane preparations. Brain Research 600:127-133.
- Leonard, S., Logel, J., Luthman, D., Casinova, M., Kirch, D., and Freedman, R. (1993). Biological stability of mRNA isolated from human postmortem brain collections. Biol. Psychiatry 33:456-466.
- Drebing, C.J., Sikela, J.M., Hopkins, J.A., Byerley, W., Khan, A.S., Leonard, S., and Freedman, R. (1993). Method to detect mutations in the beta-nerve growth factor gene in schizophrenics and normals by fluorescent sequencing. Psychiatric Gen. 3:21-27.
- Leonard, S., Luthman, D., Logel, J., Luthman, J., Antle, C., Freedman, R., and Hoffer, B. (1993). Acidic and basic fibroblast growth factor mRNAs are increased in striatum following MPTP-induced dopamine neurofiber lesion: assay by quantitative PCR. Mol. Brain Res. 18:275-284.
- Freedman, R., Wetmore, C., Strömberg, I., Leonard, S., and Olson, L. (1993). α-Bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J. Neurosci. 13:1965-1975.
- Lin, L.-H., Leonard, S., and Harris, R.A. (1993). Enflurane inhibits the function of mouse and human brain phosphatidylinositol-linked acetylcholine and serotonin receptors expressed in Xenopus oocytes. Mol. Pharm. 43:941-948.
- Browning, M.D., Dudek, E.M., Rapier, J.L., Leonard, S., and Freedman, R. (1993). Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics. Biol. Psychiatry 34:529-535.
- Breese, C.R. and Leonard, S.S. (1994). Glutamate receptor subtype expression in human postmortem brain. J. Mol. Neurosci. 4:263-275.
- Coon, H., Sobell, J., Heston, L., Sommers, S., Hoff, M., Holik, J., Umar, F., Robertson, M., Reimherr, F., Wender, P., Vest, K., Myles-Worsley, M., Gershon, E.S., DeLisi, L.E., Shields, G., Dale, P.W., Polloi, A., Waldo, M., Leonard, S., Sikela, J., Freedman, R., and Byerley, W. (1994). Search for mutations in the ß1 GABAA receptor subunit gene in patients with schizophrenia. Neuropsychiatric Genetics 54:12-20.
- Freedman, R., Adler, L.E., Bickford, P., Byerley, W., Coon, H., Cullum, C.M., Griffith, J.M., Harris, J.G., Leonard, S., Miller, C., Myles-Worsley, M., Nagamoto, H.T., Rose, G., and Waldo, M. (1994). Schizophrenia and nicotinic receptors. Harvard Rev. Psych. 2:179-192.Breese, C.R., Freedman, R., and Leonard, S.S. (1995). Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Research 674:82-90.
- Leonard, S. (1995). In vitro transcription of cRNA from PCR-generated DNA fragments. In: Methods in Neurosciences: PCR in Neuroscience, Vol 26:243-251.
- Khan, A.S., Freedman, R., Byerley, W., and Leonard, S. (1995). Temperature gradient gel electrophoresis (TGGE) analysis of the ß-NGF gene in schizophrenia. J. Psychiatry Neurosci. 20:199-209.
- Freedman, R., Hall, M., Adler, L.E., and Leonard, S. (1995). Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol. Psychiatry 38:22-33.
- Freedman, R., Leonard, S., Adler, L., Bickford, P., Byerley, W., Coon, H., Miller, C., Luntz-Leybman, V., Myles-Worsley, M., Nagamoto, H., Rose, G., Stevens, K., and Waldo, M. (1995). Nicotinic receptors and the pathophysiology of schizophrenia. In: Advances in Pharmacological Sciences: Effects of Nicotine on Biological Systems II. P.B.S. Clarke, M. Quik, F. Adlkofer, and K. Thurau (eds), Birkhauser Verlag Basel, pp. 307-312.
- Breese, C.R., D’Costa, A., Rollins, Y.D., Adams, C., Booze, R.M., Sonntag, W.E., and Leonard, S. (1996). Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. J. Comp. Neurol. 369:388-404.
- Stevens, K.E., Freedman, R., Collins, A.C., Hall, M., Leonard, S., Marks, M.J., and Rose, G.M. (1996). Genetic correlation of inhibitory gating of hippocampal auditory evoked response and α-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychophramacology 15:152-162.
- Leonard, S., Adams, C., Breese, C.R., Adler, L.E., Bickford, P., Byerley, W., Coon, H., Griffith, J.M., Miller, C., Myles-Worsley, M., Nagamoto, H.T., Rollins, Y., Stevens, K.E., Waldo, M., and Freedman, R. (1996). Nicotinic receptor function in schizophrenia (Review). Schizophrenia Bulletin 22:431-445.
- Williamson, P.C., Brauer, M., Leonard, S., Thompson, T., and Drost, D. (1996). 31P magnetic resonance spectroscopy studies in schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids 55:115-118.
- Breese, C.R., Logel, J., Adams, C., and Leonard, S.S. (1996). Regional gene expression of the glutamate receptor subtypes GluR1, GluR2, and GluR3 in human postmortem brain. J. Mol. Neurosci. 7:277-289.
- Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., Rosenthal, J., Waldo, M.C., Reimherr, F., Wender, P., Yaw, J., Young, D.A., Breese, C.R., Adams, C., Patterson, D., Adler, L.E., Kruglyzk, L., Leonard, S., and Byerley, W. (1997). Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. 94:587-592.
- Breese, C.R., Marks, M.J., Logel, J., Adams, C.E., Sullivan, B., Collins, A.C., and Leonard, S. (1997). Effect of smoking history on [3H] nicotine binding in human postmortem brain. J. Pharm. Exper. Therapeut. 282:7-13.
- Breese, C.R., Adams, C., Logel, J., Drebing, C., Rollins, Y., Barnhart, M., Sullivan, B., Demasters, B.K., Freedman, R., and Leonard, S. (1997). Comparison of the regional expression of nicotinic acetylcholine receptor α7 mRNA and [125I]-α-bungarotoxin binding in human postmortem brain. J. Comp. Neurol. 387:385-398.
- Robinson, W.P., Horsthemke, B., Leonard, S., Malcolm, S., Morton, C., Nicholls, R.D. Ritchie, R.J., Rogan, P., Schultz, R., Schwartz, S., Sharp, J., Trent, R., Wevrick, R., Williamson, M., and Knoll, J.H.M. (1997). Report of the Third International Workshop on Human Chromosome 15 Mapping. Cytogen. Cell Gen. 76:1-13.
- Frazier, C.J., Rollins, Y.D., Breese, C.R., Leonard, S., Freedman, R. and Dunwiddie, T.V. (1998). Acetylcholine activates an α-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J. Neurosci. 18:1187-1195.
- Leonard, S., Gault, J., Moore, T., Hopkins, J., Robinson, M., Olincy, A., Adler, L.E., Cloninger, C.R., Kaufmann, C.A., Tsuang, M.T., Faraone, S.V., Malaspina, D., Svrakic, D.M., and Freedman, R. (1998). Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative. Am. J. Med. Gen.- Neuropsychiatric Genetics 81:308-312.
- Adler, L.E., Olincy, A., Waldo, M., Harris, J.G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., and Freedman, R. (1998). Schizophrenia, sensory gating, and nicotinic receptors. Schizophrenia Bulletin 24:189-202.
- Leonard, S., Gault, J., Adams, C., Breese, C.R., Rollins, Y., Adler, L.E., Olincy, A., and Freedman, R. (1998). Nicotinic receptors, smoking and schizophrenia. Restorative Neurol. Neurosci. 12:195-201.
- Gault, J., Robinson, M., Berger, R., Drebing, C., Logel, J., Hopkins, J., Moore, T., Jacobs, S., Merriwether, J., Choi, M.J., Kim, E.J., Walton, K., Buiting, K., Davis, A., Breese, C., Freedman, R., and Leonard, S. (1998). Genomic organization and partial duplication of the human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics 52:173-185.
- Leonard, S., Adler, L.E., Olincy, A., Breese, C.R., Gault, J., Ross, R.G., Lee, M., Cawthra, E., Nagamoto, H.T., and Freedman, R. (1998). The role of nicotine and nicotinic receptors in psychopathology. In: Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities, S.P. Arneric and J.D. Brioni (eds), John Wiley & Sons, New York, pp. 307-321.
- Leonard, S. and Freedman, R. (1998). Nicotinic receptor pathology: is it present in schizophrenia? SRNT Newsletter 4:6-8.
- Olincy, A., Leonard, S., Young, D.A., Sullivan, B., and Freedman, R. (1999). Decreased bombesin peptide response to cigarette smoking in schizophrenia. Neuropsychopharmacology 20:52-59.
- Freedman, R., Adler, L.E., and Leonard, S. (1999). Alternative phenotypes for the complex genetics of schizophrenia. Biol. Psych. 45:551-558.
- Craddock, N., Lendon, C., Cichon, S., Culverhouse, R., Detera-Wadleigh, S., Devon, R., Faraone, S., Foroud, T., Gejman, P., Leonard, S., McInnis, M., Owen, M.J., Riley, B., Armstrong, C., Barden, N., van Broeckhoven, C., Ewald, H., Folstein, S., Gerhard, D., Goldman, D., Gurling, H., Kelsoe, J., Levinson, D., Muir, W., Philippe, A., et al. (1999). Chromosome workshop: chromosomes 11, 14, and 15. American Journal of Medical Genetics 88(3):244-254.
- Peng, J.-H., Lucero, L., Fryer, J., Herl, J., Leonard, S.S., and Lukas, R.J. (1999). Inducible, heterologous expression of human α7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line. Brain Res. 825:172-179.
- Morton, C.C., Christian, S.L., Donlon, T.A., Driscoll, D.J., Fink, J.K., Gabriel, J.M., Gotway, G., Greally, J.M., Hitchins, M.P., Howard, H.C., Ji, Y., Leonard, S., Lerner, T., Magenis, E., Malcolm, S., Ohta, T., Rainier, S., Rees, M., Riley, B., Robinson, W.P., Saitoh, S., Schultz, R., Sell, S., Sharp, J.D., Nicholls, R.D., et al. (1999). Report of the fourth international workshop on human chromosome 15 mapping. Cytogen. Cell Gen. 84:12-21.
- Waldo, M.C., Adler, L.E., Leonard, S., Olincy, A., Ross, R.G., Harris, J.G., and Freedman, R. (2000). Familial transmission of risk factors in the first-degree relatives of schizophrenic people. Biol. Psych. 47:231-239.
- Yao, J.K., Leonard, S., and Reddy, R.D. (2000). Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schiz. Res. 42:7-17.
- Leonard, S., Breese, C., Adams, C., Benhammou, K., Gault, J., Stevens, K., Lee, M., Adler, L., Olincy, A., Ross, R., and Freedman, R. (2000). Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur. J. Pharm. 393:237-242.
- Stitzel, J.A., Leonard, S.S., and Collins A.C. (2000). Genetic regulation of nicotine-related behaviors and brain nicotinic receptors. In: Neuronal Nicotinic Receptors. F. Clementi, C. Gotti, and D. Fornasari (eds), Springer-Verlag (Berlin, Heidelberg, New York), pp. 563-585.
- Weiland, S., Bertrand, D., and Leonard, S. (2000). Neuronal nicotinic acetylcholine receptors: from the gene to the disease. Behavioral Brain Research 113:43-56.
- Breese, C.R., Lee, M.J., Adams, C.E., Sullivan, B., Logel, J., Gillen, K.M., Marks, M.J., Collins, A.C., and Leonard, S. (2000). Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology 23:351-364.
- Freedman, R., Adams, C.E., Adler, L.E., Bickford, P.C., Gault, J., Harris, J.G., Nagamoto, H.T., Olincy, A., Ross, R.G., Stevens, K.E., Waldo, M., and Leonard, S. (2000). Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia. J. Med. Gen. (Semin. Med. Genet.) 97:58-64.
- Freedman, R., Adams, C.E., Leonard, S. (2000) The alpha 7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. J. Chem. Neuroanat. 20: 299-306.
- Benhammou, K., Lee, M., Strook, M.A., Sullivan, B., Logel, J., Raschen, K., Gotti, C., and Leonard, S. (2000). [3H] Nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day. Neuropharmacology 39:2818-2829.
- McCallum, S.E., Caggiula, A.R., Booth, S., Breese, C.R., Lee, M.J., Donny, E.C., Leonard, S., and Sved, A.F. (2000). Mecamylamine prevents tolerance but enhances whole brain [3H] epibatidine binding in response to repeated nicotine administration in rats. Psychopharmacology 150:1-8.
- Buervenich, S., Carmine, A., Arvidsson, M., Xiang, F., Zhang, Z., Sydow, O., Jönsson, E.G., Sedvall, G.C., Leonard, S., Ross, R.G., Freedman, R., Chowdari, K.V., Nimgaonkar, V.L., Perlmann, T., Anvret, M., and Olson, L. (2000). NURR1 mutations in cases of schizophrenia and manic depressive disorder. Am. J. Med. Gen., Neuropsych. Gen. 96:808-813.
- Lee, M.J., Breese, C.R., and Leonard, S. (2001). The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain. Mol. Brain Res. 86:115-124.
- Freedman, R., Leonard, S., Gault, J.M., Hopkins, J., Cloninger, C.R., Kaufmann, C.A., Tsuang, M.T., Faraone, S.V., Malaspina, D., Svrakic, D.M., Sanders, A., and Gejman, P. (2001). Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the α7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am. J. Med. Gen., Neuropsych. Gen. 105:20-22.
- Freedman, R., Leonard, S., Olincy, A., Kaufmann, C.A., Malaspina, D., Cloninger, R., Svrakic, D., Faraone, S.V., and Tsuang, M.T. (2001). Evidence for the multigenic inheritance of schizophrenia. Am. J. Med. Gen. (Neuropsych. Gen) 105:794-800.
- Leonard, S. and Bertrand, D. (2001). Neuronal nicotinic receptors: from structure to function. Nicotine & Tobacco Research 3:203-223.
- Freedman,R. and Leonard,S. (2001). Genetic linkage to schizophrenia at chromosome 15q14. American Journal of Medical Genetics 105, 655-657.Leonard, S., Adler, L.E., Benhammou, K., Berger, R., Breese, C.R., Drebing, C., Gault, J., Lee, M.J., Logel, J., Olincy, A., Ross, R.G., Stevens, K., Sullivan, B., Vianzon, R., Vernich, D.E., Waldo, M., Walton, K., and Freedman, R. (2001). Smoking and mental illness. Pharmacol. Biochem. Behav. 70:561-570.
- Freedman, R., Adler, L.E., Olincy, A., Waldo, M.C., Ross, R.G., Stevens, K.E., Leonard, S. (2002) Input dysfunction, schizotypy, and genetic models of schizophrenia. Schiz. Res. 54:25-32.
- Leonard, S. and Giordano, L. Are differential behavioral responses to smoking and smoking cessation in schizophrenia related to nicotinic receptor levels? (2002) Neuropsychopharmacol. 27:1082-1083.
- Leonard,S., Gault,J., Hopkins,J., Logel,J., Drebing,C., Vianzon,R., Short,M., Berger,R., Robinson,M., Freedman,R. (2002) Promoter variants in the nAChRα 7 gene are associated with schizophrenia and with a sensory processing deficit found in the disease. Archives of General Psychiatry 59:1085-1096.
- Ross RG, Olincy A, Mikulich SK, Radant AD, Harris JG, Waldo M, Compagnon N, Heinlein S, Leonard S, Zerbe GO, Adler L, Freedman R. (2002) Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology 39:809-819.
- Leonard, S. and Freedman, R. Recombination in a schizophrenic probands fails to exclude CHRNA7 at chromosome 15q14. (2003) Mol. Psych. 8:145-146.
- Gault,J., Hopkins,J., Berger,R., Drebing,C., Logel,J., Walton,K., Short,M., Vianzon,R., Olincy,A., Ross,R.G., Adler,L.E., Freedman,R., Leonard,S. (2003) Comparison of Polymorphism in the α7 Nicotinic Receptor Gene Cluster in Schizophrenic and Control Subjects. Am. J. Med. Gen. 123B (1): 39-49.
- Leonard, S. (2003) Consequences of low levels of nicotinic receptor gene expression in schizophrenia for drug development. Drug Dev. Res. 60:127-136.
- Freedman R. Olincy A. Ross RG. Waldo MC. Stevens KE. Adler LE. Leonard S. The genetics of sensory gating deficits in schizophrenia. (2004) Current Psychiatry Reports. 5(2):155-61.
- Yao, J.K., Leonard, S., and Reddy, R.D. Increased nitric oxide radicals in postmortem brain from patients with schizophrenia. (2004) Schizophrenia Bulletin 30:923-934.
- Peng, J-H., Fryer, J.D., Hurst, R.S., Schroeder, K.M., George, A.A., Morrissy, S., Groppi, V.E., Leonard, S.S., Lukas, R.J. (2005) High-affinity epibatidine binding of functional, human α7-nicotinic acetylcholine receptors heterologously expressed de Novo in Human Sh-EP1 Cells. J. P. E. T. 313:24-35.
- Freedman, R., Ross, R., Leonard, S., Myles-Worsley, M., Adams, C.E., Waldo, M., Tregellas, J., Martin, L., Olincy, A., Tanabe, J., Kisley, M.A., Hunter, S., Stevens, K.E. (2005) Early biomarkers of psychosis. Dialogues in Clinical Neuroscience 7:17-29.
- Mexal, S., Frank, M., Berger, R., Ross, R.G., Freedman, R., Leonard, S. (2005) Differential Modulation of Gene Expression in the NMDA Postsynaptic Density of Schizophrenic and Control Smokers. Molecular Brain Research 139:317-332.
- Freedman, R., Leonard, S. Waldo, M., Gault, J., Adler, L. Olincy, A. (2006) Characterization of Allelic Variants at Chromosome 15q14 in Schizophrenia. Genes, Brain, Behav. 5 (Suppl 1): 14-22.
- Yao, J.K., Leonard, S., Reddy R. (2006) Altered glutathione redox state in schizophrenia. Disease Markers 22:83-93.
- Leonard, S. and Freedman, R. (2006) Genetics of chromosome 15q in schizophrenia. Biological Psychiatry 60:115-122.
- Leonard, S. and Adams, C.E. (2006) Smoking cessation and schizophrenia. Am J. Psych. 163:11.
- Backman, C.M., Shan, L., Zhang, Y.J., Hoffer, B.J., Leonard, S., Troncoso, J.C., Vonsatel, P. Tomac, A.C. (2006) Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson’s disease: A real-time PCR study. Mol. Cell. Endocrinol. 252:160-166.
- Ann Olincy, Josette G. Harris, Lynn L. Johnson, Vicki Pender, Susan Kongs, Diana Allensworth, Jamey Ellis, Gary O. Zerbe, Sherry Leonard, Karen E. Stevens, James O. Stevens, Laura Martin, Lawrence E. Adler, Ferenc Soti, William R. Kem & Robert Freedman. (2006) Proof-of-concept trial of an α7-nicotinic agonist in schizophrenia. Arch. Gen. Psych. 63:630-638.
- Mexal, S., Berger, R., Adams, C.A., Ross, R.G., Freedman, R., Leonard, S. (2006) Brain pH has a significant impact on human postmortem hippocampal gene expression profiles. Brain Research 1106: 1-11.
- Shannon G. Matta, David J. Balfour, Neal L. Benowitz, R. Thomas Boyd, Jerry J. Buccafusco, Anthony R. Caggiula, Caroline R. Craig, Alan C. Collins, William A. Corrigall, M. Imad Damaj, Eric C. Donny, Phillip S. Gardiner, Sharon R. Grady, Ulrike Heberlein, Sherry S. Leonard, Edward D. Levin, Ronald J. Lukas, Athina Markou, Mike J. Marks, Sarah E. McCallum, Neerja Parameswaran, Kenneth A. Perkins, Marina R. Picciotto, Maryka Quik, Jed E. Rose, Adrian Rothenfluh, William R. Schafer, Ian P. Stolerman, Rachel F. Tyndale, Jeanne M. Wehner, Jeffrey M. Zirger. (2007) Guidelines for Nicotine Dose Selection for In Vivo Research. Psychopharmacology 190:269-319.
- Hope, B.T., Nagarkar, D., Leonard, S., Wise, R.A. (2007) Long-term upregulation of protein kinase A and adenylate cyclase levels in human smokers. J. Neurosci. 27:1964-1972. PMCID: PMC2575739
- Martin, L.F., Leonard, S., Hall, M-H., Tregellas, J., Freedman, R., Olincy, A. (2007) Sensory gating and alpha-7 nicotinic receptor promoter region allelic variants in schizoaffective disorder, bipolar type. Am. J. Med. Gen. Part B. 144B:611-614. PMCID: PMC3123155
- Leonard, S. and Adams, C.E. Smoking cessation and schizophrenia. (2007) Am. J. Psych. 162:1877.
- Leonard, S., Mexal, S., Freedman, R. (2007) Smoking, genetics and schizophrenia: Evidence for self medication. J. Dual Diagnosis 3:43-59. PMCID: PMC2613326
- Wagner, B.D., Zerbe, G.O., Mexal, S., and Leonard, S.S. (2008) Permutation based adjustments for the significance of partial regression coefficients in microarray data analysis. Genet Epidemiol, 32:1-8.
- Mexal, S., Berger, R., Pearce, L., Barton, A., Logel, J., Adams, C.E., Ross, R.G., Freedman, R., Leonard, S. (2008) Regulation of a novel αN-catenin splice variant in schizophrenic smokers. Am J. Med. Gen. Part B, 147B:759-768. PMCID: PMC2701353
- Stephens, S.H., Logel, J., Barton, A., Franks, A., Schultz, J., Short, M., Dickenson, J., James, B., Fingerlin, T.E., Wagner, B., Hodgkinson, C., Graw, S., Ross, R.G., Freedman, R., Leonard, S. (2009) Association of the 5’-upstream regulatory region of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schiz. Res. 109: 102-112. PMCID: PMC2748327
- Miller, C.L., Murakami, P., Ruczinski, I., Ross, R.G., Sinkus, M., Sullivan, B., Leonard, S. (2009) Two complex genotypes incorporating loci relevant to kynurenine pathway and melanotropin function are associated with schizophrenia and bipolar disorder. Schiz. Res. 113:259-267. PMCID: PMC2855687
- Sinkus, M.L., Lee, M.J., Gault, J., Logel, J., Short, M. Freedman, R. Christian, S.L., Lyon, J., Leonard, S. (2009) A 2-base pair deletion polymorphism in the partial duplication of the α7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 1291:1-11. PMCID: PMC2747474
- Mexal, S., Berger, R., Logel, J., Ross, R.G., Freedman, R., Leonard, S., (2010) Differential regulation of α7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers. J. Mol. Neurosci. 40:185-195. Erratum: 40:267. PMCID: PMC2808436
- Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE (2010) Cholinergic mechanisms, early brain development, and risk for schizophrenia. J. Child Psychol. Psychiatry, 51(5): 535-549. PMCID: PMC2862788
- Conklin, S.M., Runyan, C., Leonard, S., Reddy, R.D., Muldoon, M.F., Yao, J.K. (2010) Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder. Prostaglandins, Leukotri Essent Fatty Acids 82:111-119. PMCID: PMC2955405
- Talkowski, M.E., McCann, K.L., Chen, M., McClain, L., Bamne, M., Wood, J., Chowdari, K.V., Watson, A., Prasad, K.M., Kirov, G., Georgieva, L., Toncheva, D., Mansour, H., Lewis, D.A., Owen, M., O’Donovan, M., Papasaikas, P., Sullivan, P., Ruderfer, D., Yao, J.K., Leonard, S., Thomas, P., Miyajima, F., Quinn, J., Lopez, A.J., and Nimgaonkar, V.L. (2010) Fine-mapping reveals novel alternative splicing of the dopamine transporter. Am. J. Med. Gen. Part B 158B:1434-1447. PMID: 20957647, PMCID pending.
- Tregellas, J.R., Tanabe, J., Rojas, D.C., Shatti, S., Olincy, A., Johnson, L., Martin, L.F., Soti, F., Kem, W.R., Leonard, S., Freedman, R. (2011) Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol. Psych. 69:7-11 PMCID: PMC3005969
- Sinkus, M.L., Wamboldt, M.Z., Barton, A., Fingerlin, T.E., Laudenslager, M.L., Leonard, S. (2010) The α7 nicotinic acetylcholine receptor and the acute stress response: Maternal genotype determines offspring phenotype. Physiology and Behavior 104:321-326. PMCID: PMC3094732
- Neeley, E.W., Berger, R., Koenig, J.I., Leonard, S. (2011) Strain dependent effects of prenatal stress on gene expression in the rat hippocampus. Physiology and Behavior 104:334-339. PMCID: PMC3118943
- Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Leonard, S., Adams, C.A., Stevens, K.E. (2011) Maternal stress during the prenatal period causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety and body mass. (2011) Physiology and Behavior 104:340-347. NIHMS287294
- Neeley, E.W., Berger, R., Koenig, J.I., Leonard, S. (2011) Prenatal stress differentially alters hippocampal BDNF expression and signaling across rat strains. Neuroscience 187:24-35. PMCID: PMC3114039
- Araud, T., Graw, S., Berger, R., Lee, M., Neveu, E., Bertrand, D., Leonard, S. (2011) The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene is a dominant negative regulator of α7*nAChR function. Biochem. Pharmacol. 82:904-914. PMCID: PMC3162115
- Greenwood, T.A., Lazzeroni, L.C., Murray, S.S., Cadenhead, K.S., Calkins, M.E., Dobie, D.J., Green, M.F., Gur, R.E., Gur, R.C., Hardiman, G., Kelsoe, J.R., Leonard, S., Light, G.A., Nuechterlein, K.H., Olincy, A., Radant, A.D., Schork, N.J., Seidman, L.J., Siever, L.J., Silverman, J.M., Stone, W.S., Swerdlow, N.R., Tsuang, D.W., Tsuang, M.T., Turetsky, G.I., Freedman, R., Braff, D.L. (2011) Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am. J. Psychiatry 168:930-946.
- Canastar, A., Logel, J., Graw, S., Schultz, J.A., Osborne, C., Palionyte, M., Drebing, C., Plehaty, M., Wilson, L., Eyeson, R., Leonard, S. (2012) DNA methylation and tissue-specific transcription of the α7 nicotinic receptor gene, CHRNA7. J. Mol. Neuroscience 47:389-400.
- Schultz, J.F., Canastar, A., Short, M., El Gazzar, M., Leonard, S. (2011) Transcriptional repression of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by AP-2 alpha. J. Biol. Chem. 286:42123-42132. PMCID: PMC3234925
- Graw S, Swisshelm K, Floyd K, Carstens B, Ross R, Leonard S. (2012) Isochromosome 13 in a patient with childhood-onset schizophrenia. Mol. Cytogenet. 5:2. PMCID: PMC3274485
- Stephens, S.H., Franks, A., Berger, r., Palionyte, M., Fingerlin, R.E., Wagner, B., Logel, J., Olincy, A., Ross, R.G., Freedman, R., Leonard, S. (2012) Multiple genes in the 15q13-q14 region are associated with schizophrenia. Psychiatric Genetics 22:1-14.
- Bongiovanni, R., Leonard, S., Jaskiw, G.E. (2013) A simplified method to quantify dysregulated tyrosine transport in schizophrenia. Schiz. Res.150:386-391.
- Sinkus, M.L., Adams, C.E., Logel, J., Freedman, R., Leonard, S. (2013) Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. Brain Behav. Imm. 32:51-62.
- Schulz, K.M., Andrud, K.M., Burke, M.B., Pearson, J.N., Kreisler, A.D., Stevens, K.E., Leonard, S., Adams, C.E. (2013) The effects of prenatal stress on apha4 beta 2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring. Dev. Neurobiol. 73:806-814.
- Schulz, K.M., Pearson, J.N., Gasparrini, M.E., Brooks, K.F., Drake-Frazier, C., Zajkowski, M.E., Kreisler, A.D., Adams, C.E., Leonard, S., Stevens, K.E. (2014) Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors. Behav. Brain Res. 268:104-110.
- Ross, R.G., Hunter, S.K., McCarthy, L., Beuler, J., Hutchison, A.K., Wagner, B.D., Leonard, S., Stevens, K.E., Freedman, R. (2014) Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am. J. Psych. 170:290-298.
- Sherry Leonard, (2014) Nicotinic Receptors and Mental Illness. In Nicotinic Receptors, R. Lester and P. Kenny, Editors, Humana Press, New York, pp 417-434.
- Ying Wang, Cheng Xiao, Tim Indersmitten, Robert Freedman, Sherry Leonard, and Henry A. Lester. (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7. J. Biol. Chem. 289: 26451-26463.
- Sinkus, M.L., Graw, S., Freedman, R., Ross, R.G., Lester, H.A., Leonard, S. (2015) The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation and function. Neuropharmacol. 96:274-288. PMC4486515. NIHMS665644
- Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R (2016). Perinatal phosphatidylcholine supplementation and offspring early childhood behavior problems: Evidence for CHRNA7 moderation. American Journal of Psychiatry,173:509-516. doi: 10.1176/appi.ajp.2015.15091188 PMID: 26651393 PMCID: PMC Journal – In Process
- Freund, R.K., Graw, S., Choo, K.S., Stevens, K.E., Leonard, S., Dell’Acqua, M.L. (2016) Genetic knockout of the α7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci. Lett. 627:1-6